![]() This special will celebrate her timeless voice, unforgettable spirit and the immense impact she left on our genre through the best form of healing we have - music.” Naomi Judd had a longtime battle with mental illness. ![]() “While we all continue to deeply mourn the loss of such a legendary artist, we are honored to commemorate her legacy alongside the country community, her friends, family and legions of fans across the world at the perfect venue: The Mother Church of Country Music. “We are sincerely privileged to work alongside Wynonna and Ashley to present this live celebration of life for their mother Naomi,” a statement about the event read, according to the network. Musical performances and appearances for the commercial-free broadcast will be announced in the coming days, CNN reported. “Naomi Judd: A River of Time Celebration” will go live from Ryman Auditorium in Nashville, Tennessee, at 6 p.m. Sisters Wynonna and Ashley Judd are partnering with CMT and Sandbox Live on a public memorial special to honor their late mother, Naomi. Wynonna Judd ‘healed’ by touring after mother Naomi’s death Wynonna Judd still ‘healing’ over mom Naomi’s death: ‘Blinded by sadness’ ![]() Wynonna Judd’s CMT Awards tribute to late ‘mama’ Naomi: ‘You need to be here’ Light-activatable light-switchable optogenetics phytochrome stimulus-responsive synthetic biology synthetic virology viral gene delivery.ACM host Dolly Parton teases threesome with Garth Brooks, Trisha Yearwood In 1980, she and her daughter Wynonna (born Christina Claire) formed the duo known as The Judds, which became a very successful country music act, winning five Grammy Awards and nine Country Music Association awards. Our current light-triggered viral gene delivery prototype may be broadly useful for genetic manipulation of cells ex vivo or in vivo in transgenic model organisms, with the ultimate prospect of achieving dose- and site-specific gene expression profiles for either therapeutic (e.g., regenerative medicine) or fundamental discovery research efforts. Naomi Judd (born Diana Ellen Judd Janu April 30, 2022) 3 4 5 was an American country music singer. Overall, our successful use of light-switchable proteins in virus capsid engineering extends these important optogenetic tools into the adjacent realm of nucleic acid delivery and enables enhanced, tunable, and spatially controllable regulation of viral gene delivery. We also demonstrate spatial control of gene delivery using projected patterns of codelivered R and FR light. By modulating the ratio of R to FR light, the gene delivery efficiency can be tuned to as little as 35% or over 600% of the unengineered AAV. ![]() Upon exposure to R light, AAV engineered to display PIF6 motifs on the capsid bind to PhyB tagged with a nuclear localization sequence (NLS), resulting in significantly increased translocation of viruses into the host cell nucleus and overall gene delivery efficiency. We used the previously engineered red (R)/far-red (FR) light-switchable protein phytochrome B (PhyB) and its R light dependent interaction partner phytochrome interacting factor 6 (PIF6) from Arabidopsis thaliana to engineer an adeno-associated virus (AAV) platform whose gene delivery efficiency is controlled by light. Light is an attractive stimulus because it does not cross-react with cellular signaling networks, has negligible toxicity, is noninvasive, and can be applied in space and time with unparalleled precision. Gene delivery vectors that are activated by external stimuli may allow improved control over the location and the degree of gene expression in target populations of cells. ![]()
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